AIDS Prevention Initiative in Nigeria, Ltd./Gte. (APIN) is a non-governmental organization registered with the Nigerian Corporate Affairs Commission (CAC). APIN has built a strong partnership with the Nigerian Government, which is memorialized through a memorandum of understanding (MOU) with the National Planning Commission. APIN is a leading Nigerian organization in the provision of prevention, care and treatment services to patients with HIV/AIDS and other diseases of public health significance. Its operating experience in Nigeria dates back to 2000, when the Harvard School of Public Health (HSPH) initiated HIV/AIDS research and prevention initiatives in Nigeria, with funding from the Bill & Melinda Gates Foundation. In 2004, the HSPH project started implementing HIV/AIDS prevention, care and treatment programs with support from the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR). These activities culminated in the establishment of APIN as an independent NGO in 2007, with the aim of building local capacity and sustainability of HIV/AIDS and other diseases programming in Nigeria. Presently, APIN operates as a direct implementing partner to CDC having just completed a 3-year transition from Harvard in line with the US Government’s goal of transitioning programs to local indigenous organizations. In the four years since its operations as an implementing partner of the CDC, APIN has managed a cumulative budget of more than $50m, a reflection of the growing confidence of the USG that APIN has built enough systems to operate as an independent implementing partner of US funds. In addition to the US funded activities, APIN is currently soliciting for other funding opportunities to diversify its funding base in the wider public health arena as part of its response to current health challenges and its overall sustainability plan.